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Underground labs in China are devising potent new opiates faster than authorities can respond

Last July, police and scientists here were bracing for a new villain—perhaps the deadliest fentanyl cousin yet. "We were hearing about something so dastardly we had to be prepared," recalls Lakshmi Sammarco, the coroner for Hamilton County, which includes Cincinnati. Carfentanil, an elephant tranquilizer that apparently had never been studied in humans, was showing up mixed into heroin in nearby cities and felling addicts. That month, a Canadian man was arrested in Calgary after authorities intercepted a 1-kilogram package of carfentanil labeled as "printer accessories," which he had ordered from China. Other synthetic opiates had found their way into Ohio via Canada, so it was only a matter of time before carfentanil would make the journey as well. "We all looked at each other and said, ‘Alright, buckle your seat belts, this is going to get very bumpy,’" Sammarco says. Fentanyl crosses the blood-brain barrier with ease. It binds to opioid receptors and floods the brain with dopamine, which creates intense euphoria but also slows the heart and depresses breathing. For most individuals, a lethal fentanyl dose is about 2 milligrams—an amount so minuscule that in a test tube it looks like a few grains of salt clinging to the glass.

For the original version including any supplementary images or video, visit http://www.sciencemag.org/news/2017/03/underground-labs-china-are-devising-potent-new-opiates-faster-authorities-can-respond